The Research behind
NeuroCatch®
Since the earliest evoked responses were reported in 1939, there are now over 150,000 published studies on the PubMed.gov database. The NeuroCatch® Platform measures three event-related potentials (ERPs) that are direct measures of cognitive function: N100, P300, and N400 responses.
The following shows some of the published research that created the foundational work for NeuroCatch®; the benchmarking studies that were published in international peer-reviewed journals demonstrating these ERPs could be linked to established clinical neuropsychological test; and the studies that include NeuroCatch® as a primary outcome measure for cognition.
Peer Reviewed
Reference Literature
D'Arcy, R.C.N., Campbell, N. (2023). Clinical Use Case of the NeuroCatch® Platform: Treating Concussion and Unlocking Peak Brain Performance. NeuroCatch Inc.
Kirby ED, Jones CB, Fickling SD, Pawlowski G, Brodie SM, Boyd LA, Venter J, Moser N, Kalsi-Ryan S, Medvedev G and D’Arcy RCN. (2023) Real world evidence of improved attention and cognition during physical therapy paired with neuromodulation: a brain vital signs study. Frontiers in Human Neuroscience. 17:1209480. doi: 10.3389/fnhum.2023.1209480
D'Arcy, R.C.N., Campbell, N., Fickling S. (2022). A Practical and Accessible Measure of Brain Vital Signs: the NeuroCatch® Platform. NeuroCatch Inc.
Nayoung Kim, William D. Watson, Eric Caliendo, Sophie Nowak, Nicholas D. Schiff, Sudhin A. Shah, N. Jeremy Hill. (Sep 2022). Objective neurophysiological markers of cognition after pediatric brain injury. Neurology Clinical Practice. DOI: 10.1212/CPJ.0000000000200066. (Independent Study)
Fickling, S.D., Poel, D.N., Dorman, J.C., D’Arcy, R.C.N., & Munce, T.A. (2021). Subconcussive changes in youth football players: Objective evidence using brain vital signs and instrumented accelerometers. Brain Communications, fcab286.
Hajra, S. G., Liu, C. C., Fickling, S. D., Pawlowski, G. M., Song, X., & D'Arcy, R. (2021). Event Related Potential Signal Capture Can Be Enhanced through Dynamic SNR-Weighted Channel Pooling. Sensors (Basel, Switzerland), 21(21), 7258.
D'Arcy, R., Sandhu, J. K., Marshall, S., & Besemann, M. (2021). Mitigating Long-Term COVID-19 Consequences on Brain Health. Frontiers in neurology, 12, 630986.
Carrick, F. R., Pagnacco, G., Azzolino, S. F., Hunfalvay, M., Oggero, E., Frizzell, T., Smith, C. J., Pawlowski, G., Campbell, N., Fickling, S. D., Lakhani, B., & D'Arcy, R. (2021). Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management. Frontiers in neuroscience, 15, 670563. https://doi.org/10.3389/fnins.2021.670563
Fickling, S. D., Smith, A. M., Stuart, M. J., Dodick, D. W., Farrell, K., Pender, S. C., & D’Arcy, R. C. (2021). Subconcussive brain vital signs changes predict head-impact exposure in ice hockey players. Brain Communications, 3(2), fcab019. doi:10.1093/braincomms/fcab019
Ghosh Hajra, S., Gopinath, S., Liu, C.L., Pawlowski, G., Fickling, S.D., Song, X., & D’Arcy, R.C.N. (2020). Enabling event related potential assessments using low-density electrode arrays: A new technique for denoising individual channel EEG data. IEEE Xplore Digital Library, In Press.
Fickling, S.D., Greene, T., Greene, D., Frehlick, Z., Campbell, N., Etheridge, T., Smith, C., Bollinger, F., Danilov, Y., Rizzotti, R., Livingstone, A., Lakhani, B., & D’Arcy, R.C.N. (2020). Brain vital signs detect cognitive improvements during combined physical therapy and neuromodulation in rehabilitation from severe traumatic brain injury: Case report. Frontiers in Human Neuroscience. 14, 347. doi: 10.3389/fnhum.2020.00347
Smith, C., Lakhani, B., Livingstone, A., Fickling, S., Campbell, N., Tannouri, P., Danilov, Y., Sackier, J., & D’Arcy, R.C.N. (2020). Brain vital signs detect information processing differences when neuromodulation is used during cognitive skills training. Frontiers in Human Neuroscience. 14, 358. doi: 10.3389/fnhum.2020.00358
Fickling, S.D., Liu, C.C., Ghosh Hajra, S., Song, X., & D’Arcy, R.C.N. (2019). Good data? The EEG quality index for automated assessment of signal quality. IEEE XPlore. 2019, 0219-0229. doi: 10.1109/IEMCON.2019.8936246
Fickling, S.D., Bolinger, F., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Song, X., & D’Arcy, R.C.N. (2020). Distant Sensor Prediction of Event-Related Potentials. IEEE Transactions on Biomedical Engineering. 67(10), 2916 – 2924. doi: 10.1109/TBME.2020.2973617
Smith, A.N., Alford, P.A., Aubry, M., Benson, B., Black, A., Brooks, A., Burke, C., D’Arcy, R.C.N., Dodick, D., Eaves, M., Eickhoff, C., Erredge, K., Farrell, K., Finnoff, J., Fraser, D., Giza, C., Greenwald, R., Hanzel, M., Hoshizaki, B., Huston, J., Jorgenson, J., Joyner, M., Krause, D., LaVoi, N., Leaf, M., Leddy, J., Leopold, J., Margarucci, K., Margulies, S., Mihalik, J., Munce, T., Ouer, A., Podein, S., Prideaux, C., Roberts, W.O., Shen, F., Soma, D., Tabrum, M., Stuart, M.B., Wethe, J., Whitehead, J., Wiese-Bjornstal, D., & Stuart, M.J. (2019). Proceedings from the Ice Hockey Summit III: Action on Concussion. Current Sport Medicine Reports, 18(1), 23-34. doi: 10.1249/JSR.0000000000000557
Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., & D’Arcy, R.C.N. (2019). Reply: P300 amplitudes after concussion are usually decreased not increased. Brain.142(7), e33. doi: 10.1093/brain/awz147
Pawlowski, G., Ghosh Hajra, S., Fickling, S., Liu, C.C., Song, X., Robinovitch, S., Doesburg, S.M., & D’Arcy, R.C.N. (2019). Brain vital signs: Expanding from the auditory to visual modality. Frontiers in Neuroscience. 18;12:968. doi: 10.3389/fnins.2018.00968
Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., D’Arcy, R.C.N. (2019). Brain vital signs detect concussion-related neurophysiological impairment in ice-hockey. Brain, 142(2), 255-262. Editor’s Choice. doi: 10.1093/brain/awy317
Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P.L. & D’Arcy, R.C.N. (2018). Accessing knowledge of the 'here and now': A new technique for capturing electromagnetic markers of orientation processing. Journal of Neural Engineering, 16(1), 016008. doi: 10.1088/1741-2552/aae91e
Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P., & D’Arcy, R.C.N. (2018). Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework. Journal of Translational Medicine, 16(1),151. doi: 10.1186/s12967-018-1527-2
Ghosh-Hajra, S., Liu, C., Song, X., Fickling, S., Pawlowski, G. Jorgensen, J.K., Smith, A.M., Schnaider-Beeri, M., Van Den Broek, R., Rizzotti, R., Fisher, K., & D’Arcy, R.C.N. (2016). Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time. Frontiers of Neuroscience, Brain Imaging Methods. 10, 211. doi: 10.3389/fnins.2016.00211
Completed and Ongoing Research Using
the NeuroCatch® Platform
