The Research behind
NeuroCatch®


Since the earliest evoked responses were reported in 1939, there are now over 160,000 published studies on the PubMed.gov database. The NeuroCatch® Platform measures three event-related potentials (ERPs) that are direct measures of cognitive function: N100, P300, and N400 responses.

The following shows some of the published research that created the foundational work for NeuroCatch®; the benchmarking studies that were published in international peer-reviewed journals demonstrating these ERPs could be linked to established clinical neuropsychological test; and the studies that include NeuroCatch® as a primary outcome measure for cognition.



Peer Reviewed
Reference Literature


Explore current reference literature on brain vital signs and ERP/EEG. Click on the headings below to expand the lists.

D'Arcy, R.C.N., Campbell, N., Fickling S. (2022). A Practical and Accessible Measure of Brain Vital Signs: the NeuroCatch® Platform. NeuroCatch Inc.

Nayoung Kim, William D. Watson, Eric Caliendo, Sophie Nowak, Nicholas D. Schiff, Sudhin A. Shah, N. Jeremy Hill. (Sep 2022). Objective neurophysiological markers of cognition after pediatric brain injury. Neurology Clinical Practice. DOI: 10.1212/CPJ.0000000000200066. (Independent Study)

Fickling, S.D., Poel, D.N., Dorman, J.C., D’Arcy, R.C.N., & Munce, T.A. (2021). Subconcussive changes in youth football players: Objective evidence using brain vital signs and instrumented accelerometers. Brain Communications, fcab286.

Hajra, S. G., Liu, C. C., Fickling, S. D., Pawlowski, G. M., Song, X., & D'Arcy, R. (2021). Event Related Potential Signal Capture Can Be Enhanced through Dynamic SNR-Weighted Channel PoolingSensors (Basel, Switzerland), 21(21), 7258.

D'Arcy, R., Sandhu, J. K., Marshall, S., & Besemann, M. (2021). Mitigating Long-Term COVID-19 Consequences on Brain Health.Frontiers in neurology, 12, 630986.

Carrick, F. R., Pagnacco, G., Azzolino, S. F., Hunfalvay, M., Oggero, E., Frizzell, T., Smith, C. J., Pawlowski, G., Campbell, N., Fickling, S. D., Lakhani, B., & D'Arcy, R. (2021). Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion ManagementFrontiers in neuroscience15, 670563. https://doi.org/10.3389/fnins.2021.670563

Fickling, S. D., Smith, A. M., Stuart, M. J., Dodick, D. W., Farrell, K., Pender, S. C., & D’Arcy, R. C. (2021). Subconcussive brain vital signs changes predict head-impact exposure in ice hockey playersBrain Communications3(2), fcab019. doi:10.1093/braincomms/fcab019

Ghosh Hajra, S., Gopinath, S., Liu, C.L., Pawlowski, G., Fickling, S.D., Song, X., & D’Arcy, R.C.N. (2020). Enabling event related potential assessments using low-density electrode arrays: A new technique for denoising individual channel EEG data. IEEE Xplore Digital Library, In Press.

Fickling, S.D., Greene, T., Greene, D., Frehlick, Z., Campbell, N., Etheridge, T., Smith, C., Bollinger, F., Danilov, Y., Rizzotti, R., Livingstone, A., Lakhani, B., & D’Arcy, R.C.N. (2020). Brain vital signs detect cognitive improvements during combined physical therapy and neuromodulation in rehabilitation from severe traumatic brain injury: Case reportFrontiers in Human Neuroscience. 14, 347. doi: 10.3389/fnhum.2020.00347

Smith, C., Lakhani, B., Livingstone, A., Fickling, S., Campbell, N., Tannouri, P., Danilov, Y., Sackier, J., & D’Arcy, R.C.N. (2020). Brain vital signs detect information processing differences when neuromodulation is used during cognitive skills training. Frontiers in Human Neuroscience. 14, 358. doi: 10.3389/fnhum.2020.00358

Fickling, S.D., Liu, C.C., Ghosh Hajra, S., Song, X., & D’Arcy, R.C.N. (2019). Good data? The EEG quality index for automated assessment of signal quality. IEEE XPlore. 2019, 0219-0229. doi: 10.1109/IEMCON.2019.8936246

Fickling, S.D., Bolinger, F., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Song, X., & D’Arcy, R.C.N. (2020). Distant Sensor Prediction of Event-Related Potentials. IEEE Transactions on Biomedical Engineering. 67(10), 2916 – 2924. doi: 10.1109/TBME.2020.2973617

Smith, A.N., Alford, P.A., Aubry, M., Benson, B., Black, A., Brooks, A., Burke, C., D’Arcy, R.C.N., Dodick, D., Eaves, M., Eickhoff, C., Erredge, K., Farrell, K., Finnoff, J., Fraser, D., Giza, C., Greenwald, R., Hanzel, M., Hoshizaki, B., Huston, J., Jorgenson, J., Joyner, M., Krause, D., LaVoi, N., Leaf, M., Leddy, J., Leopold, J., Margarucci, K., Margulies, S., Mihalik, J., Munce, T., Ouer, A., Podein, S., Prideaux, C., Roberts, W.O., Shen, F., Soma, D., Tabrum, M., Stuart, M.B., Wethe, J., Whitehead, J., Wiese-Bjornstal, D., & Stuart, M.J. (2019). Proceedings from the Ice Hockey Summit III: Action on Concussion. Current Sport Medicine Reports, 18(1), 23-34. doi: 10.1249/JSR.0000000000000557

Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., & D’Arcy, R.C.N. (2019). Reply: P300 amplitudes after concussion are usually decreased not increased. Brain.142(7), e33. doi: 10.1093/brain/awz147

Pawlowski, G., Ghosh Hajra, S., Fickling, S., Liu, C.C., Song, X., Robinovitch, S., Doesburg, S.M., & D’Arcy, R.C.N. (2019). Brain vital signs: Expanding from the auditory to visual modality. Frontiers in Neuroscience. 18;12:968. doi: 10.3389/fnins.2018.00968

Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., D’Arcy, R.C.N. (2019). Brain vital signs detect concussion-related neurophysiological impairment in ice-hockey. Brain, 142(2), 255-262. Editor’s Choice. doi: 10.1093/brain/awy317

Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P.L. & D’Arcy, R.C.N. (2018). Accessing knowledge of the 'here and now': A new technique for capturing electromagnetic markers of orientation processing. Journal of Neural Engineering, 16(1), 016008. doi: 10.1088/1741-2552/aae91e

Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P., & D’Arcy, R.C.N. (2018). Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework. Journal of Translational Medicine, 16(1),151. doi: 10.1186/s12967-018-1527-2

Ghosh-Hajra, S., Liu, C., Song, X., Fickling, S., Pawlowski, G. Jorgensen, J.K., Smith, A.M., Schnaider-Beeri, M., Van Den Broek, R., Rizzotti, R., Fisher, K., & D’Arcy, R.C.N. (2016). Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time. Frontiers of Neuroscience, Brain Imaging Methods. 10, 211. doi: 10.3389/fnins.2016.00211


Completed and Ongoing Research Using
the NeuroCatch® Platform


Using the NeuroCatch® Platform
study title
status
conditions
location
CT Registry / Journal
Recruiting
PTSD

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT05112003

Recruiting
Depression

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT05105776

Recruiting
Parkinson’s Disease

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT05594667

Completed
Sleep Deprivation

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT05560620

Completed
Pediatric Brain Injury

WEILL CORNELL MEDICINE
Department of Radiology
New York, NY, USA

Completed
Brain Health
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03421405

Recruiting Complete

Traumatic Brain Injury

Concussion

MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
Site IRB:
18-004925
Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03835962

Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada

ClinicalTrials.gov:
NCT03889483

Recruiting
Brain Injuries
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03438851

Recruiting

Alzheimer Disease,

Dementia

Neuropathology

Mild Cognitive Impairment

BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada

ClinicalTrials.gov:
NCT03676881

* Denotes independent study.

Need help integrating NeuroCatch® into your research? Contact the Centre for Neurology Studies for support.

study title
status
conditions
location
reg. no.

STATUS
Completed

CONDITIONS
Pediatric Brain Injury

LOCATION
WEILL CORNELL MEDICINE
Department of Radiology
New York, NY, USA

STATUS
Completed
CONDITIONS
Brain Health
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03421405
STATUS
Recruiting Complete
CONDITIONS

Traumatic Brain Injury, Concussion

LOCATION
MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
REG. NO.
Site IRB:
18-004925
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03835962
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada
REG. NO.
ClinicalTrials.gov:
NCT03889483
STATUS
Recruiting
CONDITIONS
Brain Injuries
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03438851
STATUS
Recruiting
CONDITIONS

Alzheimer Disease, >Dementia, Neuropathology, Mild Cognitive Impairment

LOCATION
BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada
REG. NO.
ClinicalTrials.gov:
NCT03676881
* Denotes independent study.
Intended Use
The NeuroCatch® Platform is intended for the elicitation, acquisition, analysis, storage, reporting and management of electroencephalograph (EEG) and event-related potential (ERP) information to aid in diagnosis of a patient.


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