The Story of

the NeuroCatch®
Platform


The NeuroCatch® Platform represents the technology implementation of brain vital signs research, which is fully automated and aiming to provide high quality, accessible, rapid and advanced capabilities across a range of clinical points-of-care.[1]

NeuroCatch® 1.1 has been rigorously developed, tested, and is approved in Canada. It simplifies complex neuroscience into simple point-of-care cognitive evaluation delivered in minutes. NeuroCatch® 1.1 displays ERP data only. Radar plots are not generated by the current version of device.

Future NeuroCatch® advances plan to translate event-related potential (ERP) utilizing the well-established power of medical images through radar plots, a user-friendly format for visualizing high-quality data comparisons based on referenced data sets.

The following are published results from a study with the Mayo Clinic, that demonstrates the power of a visual assessment, displaying a healthy brain, an injured brain, and a recovering brain in ice-hockey players.[2]


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the future of
the neurocatch® platform


Our vision for the future of the NeuroCatch® Platform:

Boldly elevate people and positively impact a billion brains!

the future of NeuroCatch


Progression of
the NeuroCatch® Platform


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NeuroCatch Clinical

This is the first release of the NeuroCatch® Platform: NeuroCatch® 1.1, a limited release to put our unprecedented objective cognitive assessment tool into the hands of clinicians and researchers. Best-in-class for quality, access, and cost began here.
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NeuroCatch cloud

NeuroCatch® innovations launch into the cloud with a hardware platform expansion, a ramped-up user-experience interface (UX), amped up analytics under the hood, the much-anticipated intuitive report, and a surprise technology reveal that is predicted to bring unparalleled timing accuracy with millisecond resolution.*
*Product is currently in research & development and not approved for commercial use.
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NeuroCatch compact

NeuroCatch® gets smaller, faster, easier and more accessible, moving to every possible point-of-care.* It is anticipated to provide the ability to perform cognitive assessments in various locations such as field-side for athletes and in-home for occupational therapists. Our engineers and scientists are pretty jazzed up about what’s in store here. Stay tuned!

*Product is currently in research & development and not approved for commercial use.
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NeuroCatch connected

NeuroCatch® full-scale integration begins.* Whether to power up other brain health tools, rocket beyond cognition to other brain functions, or find its place in altered earthly or reduced gravitational environments, NeuroCatch® technology enables us all to reach out globally and beyond.

*Product is currently in research & development and not approved for commercial use.
ERP
  • Event-related potentials, derived from EEG[1]
  • ERPs track cognitive information processing[2]
ABC
  • Auditory sensory processing
  • Basic attention processing
  • Cognitive processing
Intended Use

The NeuroCatch® Platform is intended for the elicitation, acquisition, analysis, storage, reporting and management of electroencephalograph (EEG) and event-related potential (ERP) information.



Evolution of

the Brain Vital Signs Scientific Framework and the NeuroCatch® Platform



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The

Early Days


With the earliest evoked responses reported in 1939 and nearly 150,000 published studies in the National Library of Medicine’s PubMed.gov database, the foundational work to ensure that ERP research advances could be made clinically accessible as an objective measure of cognitive function began in the mid-1990s. By the mid-2000s, numerous benchmarking studies were published in international peer-reviewed journals demonstrating that these ERPs could be linked to established clinical neuropsychological tests. Clinically, however, ERP testing remained inaccessible because of practical barriers. It was time-consuming, onerous, and required specialized expertise to understand the results, which were complex and not clinically standardized.

To move from a research laboratory procedure to a regulatory approved clinical test, the ERP procedure was translated in 2010 to a rapid, semi-automated, point-of-care test called the Halifax Consciousness Scanner or HCS. The HCS enabled proof-of-concept studies in acquired brain injury patients within numerous clinical settings, demonstrating that ERPs could be taken out of the research setting and be accessible for point-of-care.


Brain

Vital Signs


The concept of brain vital signs came from the realization that the progress in using ERPs at point-of-care created the opportunity to envision a vital sign framework for brain function. From 2010 to present, studies have demonstrated that it was possible to refine the prior HCS protocol to move to a standardized evaluation of the peak timing and amplitudes of the N100, P300, and N400 responses. These ERP responses were transformed into a clinical ABC framework and plotted on as a healthy, normal hexagon shape using a radar plot. The brain vital sign responses were reliably measured across age ranges and more sensitive than subjective, error-prone behavioural tests to detecting changes in healthy aging, concussion, sub-concussion, moderate-severe brain injury, dementia and other neurological and mental health conditions.

The NeuroCatch® Platform represents the technology implementation of brain vital sign research, which is fully automated to provide the highest quality, most accessible and advanced capabilities across a range of clinical points-of-care. NeuroCatch® is rigorously developed, tested, and regulatory approved for use in brain health and optimization.

Completed and Ongoing
Clinical Studies

Using the NeuroCatch® Platform

STUDY TITLESTATUSCONDITIONSLOCATIONREG. NO.
Assessing Repeatability of NeuroCatch™ Platform Measurements: An Initial AssessmentCompleted- Brain HealthHEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:
NCT03421405
Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design”Recruiting Complete- Traumatic Brain Injury

- Concussion
Mayo Clinic


Rochester, Minnesota, USA
Site IRB:
18-004925
Development of a Reference Interval Database With the NeuroCatch™ PlatformRecruiting- Children, Only


- Traumatic Brain Injury

- Concussion, Mild

- Pediatric ALL
HEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:

NCT03835962
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric ConcussionRecruiting- Children, Only


- Traumatic Brain Injury

- Concussion, Mild

- Pediatric ALL
ALBERTA CHILDREN'S HOSPITAL, Department of Paediatrics

Calgary, Alberta, Canada
ClinicalTrials.gov:


NCT03889483
Assessing Brain Changes Throughout the WCBH ProgramRecruiting- Brain InjuriesHEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:


NCT03889483
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s DiseaseRecruiting- Alzheimer Disease


- Dementia


- Neuropathology


- Mild Cognitive Impairment
BRUYERERESEARCH INSTITUTE

Ottawa, Ontario, Canada
ClinicalTrials.gov:


NCT03676881
study title
status
conditions
location
CT Registry
Completed
Brain Health
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03421405

Recruiting Complete

Traumatic Brain Injury

Concussion

MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
Site IRB:
18-004925
Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03835962

Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada

ClinicalTrials.gov:
NCT03889483

Recruiting
Brain Injuries
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03438851

Recruiting

Alzheimer Disease,

Dementia

Neuropathology

Mild Cognitive Impairment

BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada

ClinicalTrials.gov:
NCT03676881

study title
status
conditions
location
reg. no.
STATUS
Completed
CONDITIONS
Brain Health
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03421405
STATUS
Recruiting Complete
CONDITIONS

Traumatic Brain Injury, Concussion

LOCATION
MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
REG. NO.
Site IRB:
18-004925
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03835962
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada
REG. NO.
ClinicalTrials.gov:
NCT03889483
STATUS
Recruiting
CONDITIONS
Brain Injuries
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03438851
STATUS
Recruiting
CONDITIONS

Alzheimer Disease, >Dementia, Neuropathology, Mild Cognitive Impairment

LOCATION
BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada
REG. NO.
ClinicalTrials.gov:
NCT03676881

Peer Reviewed
Reference Literature


FOOTNOTES
[1] The NeuroCatch® Platform is an approved Class II medical device in Canada. Medical Device License #: 102616.

[2] Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., D'Arcy, R.C.N. (2019). Brain vital signs detect concussion-related neurophysiological impairment in ice-hockeyBrain, 142(2), 255-262. Editor's Choice.doi: 10.1093/brain/awy317

disclaimer

The content on this page describes future developments planned for the NeuroCatch® Platform. It does not describe NeuroCatch® 1.1 which is currently in use.



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