Future of NeuroCatch - NeuroCatch Inc.

The Story of
the NeuroCatch^®
Platform

The NeuroCatch^® Platform represents the technology implementation of brain vital signs research, which is fully automated and aiming to provide high quality, accessible, rapid and advanced capabilities across a range of clinical points-of-care.^[1]

NeuroCatch^® has been rigorously developed, tested, and is registered with the U.S. Food & Drug Administration.^† It simplifies complex neuroscience into simple point-of-care cognitive evaluation delivered in minutes.

NeuroCatch^® displays event-related potential (ERP) data and translates these results into standardized results in radar plot, tabular, and graphical formats. Much anticipated, NCP Radar Plots™ utilize the well-established power of medical images, with a user-friendly format for visualizing high-quality data comparisons based on referenced data sets.

The following are published results from a study with the Mayo Clinic, that demonstrates the power of a visual assessment, displaying a healthy brain, an injured brain, and a recovering brain in ice-hockey players.^[2]

Learn More

the future of
the neurocatch® platform

Our vision for the future of the NeuroCatch^® Platform:

Boldly elevate people and positively impact a billion brains!

Progression of
the NeuroCatch^® Platform

NeuroCatch Clinical

Our first release of the NeuroCatch^® Platform: NeuroCatch^® 1.0/1.1, a limited release to put our unprecedented objective cognitive assessment tool into the hands of clinicians and researchers. Best-in-class for quality, access, and cost began here.

NeuroCatch cloud

NeuroCatch^® innovations have launched into the cloud with a hardware platform expansion, a ramped-up user experience interface (UX), amped-up analytics under the hood, the much-anticipated intuitive report, and a surprise technology reveal that is predicted to bring unparalleled timing precision and sensitivity to changes in cognitive processing.^†

NeuroCatch compact

NeuroCatch^® gets smaller, faster, easier and more accessible, moving to every possible point-of-care.* It is anticipated to provide the ability to perform cognitive assessments in various locations such as field-side for athletes and in-home for occupational therapists. Our engineers and scientists are pretty jazzed up about what’s in store here. Stay tuned!

* Product is currently in research & development and not approved for commercial use.

NeuroCatch connected

NeuroCatch^® full-scale integration begins.* Whether to power up other brain health tools, rocket beyond cognition to other brain functions, or find its place in altered earthly or reduced gravitational environments, NeuroCatch^® technology enables us all to reach out globally and beyond.

* Product is currently in research & development and not approved for commercial use.

ERP

Event-related potentials, derived from EEG^[1]
ERPs track cognitive information processing^[2]

ABC

Auditory sensory processing
Basic attention processing
Cognitive processing

Intended Use

^† The NeuroCatch^® Platform is intended for the elicitation, acquisition, analysis, storage, reporting and management of electroencephalograph (EEG) and event-related potential (ERP) information to aid in assessment of cognitive function of an individual.

Evolution of
the Brain Vital Signs Scientific Framework and the NeuroCatch^® Platform

The
Early Days

With the earliest evoked responses reported in 1939 and nearly 150,000 published studies in the National Library of Medicine’s PubMed.gov database, the foundational work to ensure that ERP research advances could be made clinically accessible as an objective measure of cognitive function began in the mid-1990s. By the mid-2000s, numerous benchmarking studies were published in international peer-reviewed journals demonstrating that these ERPs could be linked to established clinical neuropsychological tests. Clinically, however, ERP testing remained inaccessible because of practical barriers. It was time-consuming, onerous, and required specialized expertise to understand the results, which were complex and not clinically standardized.

To move from a research laboratory procedure to a regulatory approved clinical test, the ERP procedure was translated in 2010 to a rapid, semi-automated, point-of-care test called the Halifax Consciousness Scanner or HCS. The HCS enabled proof-of-concept studies in acquired brain injury patients within numerous clinical settings, demonstrating that ERPs could be taken out of the research setting and be accessible for point-of-care.

Brain
Vital Signs

The concept of brain vital signs came from the realization that the progress in using ERPs at point-of-care created the opportunity to envision a vital sign framework for brain function. From 2010 to present, studies have demonstrated that it was possible to refine the prior HCS protocol to move to a standardized evaluation of the peak timing and amplitudes of the N100, P300, and N400 responses. These ERP responses were transformed into a clinical ABC framework and plotted on as a healthy, normal hexagon shape using a radar plot. The brain vital sign responses were reliably measured across age ranges and more sensitive than subjective, error-prone behavioural tests to detecting changes in healthy aging, concussion, sub-concussion, moderate-severe brain injury, dementia and other neurological and mental health conditions.

The NeuroCatch^® Platform represents the technology implementation of brain vital sign research, which is fully automated to provide the highest quality, most accessible and advanced capabilities across a range of clinical points-of-care. NeuroCatch^® is rigorously developed, tested, and regulatory approved for use in brain health and optimization.

Completed and Ongoing
Clinical Studies

Using the NeuroCatch^® Platform

STUDY TITLE	STATUS	CONDITIONS	LOCATION	REG. NO.
Assessing Repeatability of NeuroCatch™ Platform Measurements: An Initial Assessment	Completed	- Brain Health	HEALTHTECHCONNEX INC. Centre for Neurology Studies Surrey, British Columbia, Canada	ClinicalTrials.gov: NCT03421405
Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design”	Recruiting Complete	- Traumatic Brain Injury - Concussion	Mayo Clinic Rochester, Minnesota, USA	Site IRB: 18-004925
Development of a Reference Interval Database With the NeuroCatch™ Platform	Recruiting	- Children, Only - Traumatic Brain Injury - Concussion, Mild - Pediatric ALL	HEALTHTECHCONNEX INC. Centre for Neurology Studies Surrey, British Columbia, Canada	ClinicalTrials.gov: NCT03835962
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion	Recruiting	- Children, Only - Traumatic Brain Injury - Concussion, Mild - Pediatric ALL	ALBERTA CHILDREN'S HOSPITAL, Department of Paediatrics Calgary, Alberta, Canada	ClinicalTrials.gov: NCT03889483
Assessing Brain Changes Throughout the WCBH Program	Recruiting	- Brain Injuries	HEALTHTECHCONNEX INC. Centre for Neurology Studies Surrey, British Columbia, Canada	ClinicalTrials.gov: NCT03889483
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease	Recruiting	- Alzheimer Disease - Dementia - Neuropathology - Mild Cognitive Impairment	BRUYERERESEARCH INSTITUTE Ottawa, Ontario, Canada	ClinicalTrials.gov: NCT03676881

study title

status

conditions

location

CT Registry

Assessing Repeatability of NeuroCatch^® Platform Measurements: An Initial Assessment

Completed

Brain Health

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03421405

Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design”

Recruiting Complete

Traumatic Brain Injury

Concussion

MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA

Site IRB:
18-004925

Development of a Reference Interval Database With the NeuroCatch^® Platform

Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03835962

Neurophysiological Measurements Using the NeuroCatch^® Platform in Pediatric Concussion

Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada

ClinicalTrials.gov:
NCT03889483

Assessing Brain Changes Throughout the WCBH Program

Recruiting

Brain Injuries

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03438851

Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease

Recruiting

Alzheimer Disease,

Dementia

Neuropathology

Mild Cognitive Impairment

BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada

ClinicalTrials.gov:
NCT03676881

study title

status

conditions

location

reg. no.

STUDY TITLE
Assessing Repeatability of NeuroCatch^® Platform Measurements: An Initial Assessment

STATUS
Completed

CONDITIONS
Brain Health

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

REG. NO.
ClinicalTrials.gov:
NCT03421405

STUDY TITLE
Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design”

STATUS
Recruiting Complete

CONDITIONS

Traumatic Brain Injury, Concussion

LOCATION
MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA

REG. NO.
Site IRB:
18-004925

STUDY TITLE
Development of a Reference Interval Database With the NeuroCatch^® Platform

STATUS
Recruiting

CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

REG. NO.
ClinicalTrials.gov:
NCT03835962

STUDY TITLE
Neurophysiological Measurements Using the NeuroCatch^® Platform in Pediatric Concussion

STATUS
Recruiting

CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada

REG. NO.
ClinicalTrials.gov:
NCT03889483

STUDY TITLE
Assessing Brain Changes Throughout the WCBH Program

STATUS
Recruiting

CONDITIONS
Brain Injuries

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

REG. NO.
ClinicalTrials.gov:
NCT03438851

STUDY TITLE
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease

STATUS
Recruiting

CONDITIONS

Alzheimer Disease, >Dementia, Neuropathology, Mild Cognitive Impairment

LOCATION
BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada

REG. NO.
ClinicalTrials.gov:
NCT03676881

Peer Reviewed
Reference Literature

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Fickling, S.D., Greene, T., Greene, D., Frehlick, Z., Campbell, N., Etheridge, T., Smith, C., Bollinger, F., Danilov, Y., Rizzotti, R., Livingstone, A., Lakhani, B., & D’Arcy, R.C.N. (2020). Brain vital signs detect cognitive improvements during combined physical therapy and neuromodulation in rehabilitation from severe traumatic brain injury: Case report. Frontiers in Human Neuroscience. 14, 347. doi: 10.3389/fnhum.2020.00347

Smith, C., Lakhani, B., Livingstone, A., Fickling, S., Campbell, N., Tannouri, P., Danilov, Y., Sackier, J., & D’Arcy, R.C.N. (2020). Brain vital signs detect information processing differences when neuromodulation is used during cognitive skills training. Frontiers in Human Neuroscience. 14, 358. doi: 10.3389/fnhum.2020.00358

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Fickling, S.D., Bolinger, F., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Song, X., & D’Arcy, R.C.N. (2020). Distant Sensor Prediction of Event-Related Potentials. IEEE Transactions on Biomedical Engineering. 67(10), 2916 – 2924. doi: 10.1109/TBME.2020.2973617

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Pawlowski, G., Ghosh Hajra, S., Fickling, S., Liu, C.C., Song, X., Robinovitch, S., Doesburg, S.M., & D’Arcy, R.C.N. (2019). Brain vital signs: Expanding from the auditory to visual modality. Frontiers in Neuroscience. 18;12:968. doi: 10.3389/fnins.2018.00968

Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., D’Arcy, R.C.N. (2019). Brain vital signs detect concussion-related neurophysiological impairment in ice-hockey. Brain, 142(2), 255-262. Editor’s Choice. doi: 10.1093/brain/awy317

Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P.L. & D’Arcy, R.C.N. (2018). Accessing knowledge of the 'here and now': A new technique for capturing electromagnetic markers of orientation processing. Journal of Neural Engineering, 16(1), 016008. doi: 10.1088/1741-2552/aae91e

Ghosh Hajra, S., Liu, C.C., Song, X., Fickling, S.D., Cheung, T.P., & D’Arcy, R.C.N. (2018). Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework. Journal of Translational Medicine, 16(1),151. doi: 10.1186/s12967-018-1527-2

Ghosh-Hajra, S., Liu, C., Song, X., Fickling, S., Pawlowski, G. Jorgensen, J.K., Smith, A.M., Schnaider-Beeri, M., Van Den Broek, R., Rizzotti, R., Fisher, K., & D’Arcy, R.C.N. (2016). Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time. Frontiers of Neuroscience, Brain Imaging Methods. 10, 211. doi: 10.3389/fnins.2016.00211

Zhang, X., D’Arcy, R.C.N., Ming, D., & Menon, C. (2020). The Feasibility of Longitudinal Upper Extremity Motor Function Assessment Using EEG. (2019), E5487. doi: 10.3390/s20195487

Liu, C.C., Ghosh Hajra, S., Pawlowski, G., Fickling, S.D., Song, X., & D’Arcy, R.C.N. (2020). Differential neural processing of spontaneous blinking under visual and auditory sensory environments: An EEG investigation of blink-related oscillations, NeuroImage. 218, 116879. doi: 10.1016/j.neuroimage.2020.116879

Liu, C.C., Ghosh Hajra, S., Fickling, S.D., Pawlowski, G., Song, X., & D’Arcy, R.C.N. (2019). Novel signal processing technique for capture and isolation of blink-related oscillations using a low-density electrode array for bedside evaluation of consciousness. IEEE Transactions on Biomedical Engineering. Epub ahead of print. 67(2), 453-463. doi: 10.1109/TBME.2019.2915185

Frehlick, Z., Lakhani, B., Fickling, S., Livingstone, A., Danilov, Y., Sackier, J., & D’Arcy, R.C.N. (2019). Human translingual neurostimulation alters resting brain activity in high-density EEG. Journal of NeuroEngineering and Rehabilitation. 16(1), 60. doi: 10.1186/s12984-019-0538-4

Magnuson, J.R., Peatfield, N.A., Fickling, S., Nunes, A.S., Christie, G., Vakorin, V., D’Arcy, R.C.N., Ribary, U., Iarocci, G., Moreno, S., & Doesburg, S.M. (2019). Electrophysiology of inhibitory control in the context of emotion processing in children with autism spectrum disorder. Frontiers in Human Neuroscience. 12,13:78. doi: 10.3389/fnhum.2019.00078

Zhang, X., D’Arcy, R.C.N., Menon, C.(2019). Scoring upper-extremity motor function from EEG using artificial intelligence. Journal of Neural Engineering. 16 (3), 036013. doi: 10.1088/1741-2552/ab0b82

Liu, C.C., Ghosh Hajra, S., Song, X., Doesburg, S., Cheung, T.P.L., & D’Arcy, R.C.N. (2019). Cognitive loading via mental arithmetic modulates effects of blink-related oscillations on precuneus and ventral attention network regions. Human Brain Mapping, 40(2), 377-393. doi: 10.1002/hbm.24378

Fleck-Prediger, C., Ghosh Hajra, S., Liu, C.C., Gray, S., Petley, L., Weaver, D.F., Gopinath, S., Yee, E., Dick, B.D., & D’Arcy, R.C.N. (2018). Point-of-care brain injury evaluation of conscious awareness: Wide scale deployment of portable HCS EEG evaluation. Neuroscience of Consciousness. 2018(1), niy011. doi: 10.1093/nc/niy011

Liu, C.C.; Ghosh Hajra, S., Cheung, T.P., Song, X., & D’Arcy, R.C.N. (2017). Spontaneous blinks activate the precuneus: Characterizing blink-related oscillations using magnetoencephalography. Frontiers in Human Neuroscience. 11, 489. doi: 10.3389/fnhum.2017.00489

D’Arcy, R.C.N., Lindsay, D.S., Song, X., Gawryluk, J.R., Greene, D., Mayo, C., Ghosh Hajra, S., Mandziuk, L., Mathieson, J., & Greene T. (2016). Long-Term Motor Recovery After Severe Traumatic Brain Injury: Beyond Established Limits. Journal of Head Trauma Rehabilitation. 31(5), E50-8. doi: 10.1097/HTR.0000000000000185

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Parvar, H., R., Sculthorpe-Petley, L., Satel, J., Boshra, D’Arcy, R.C.N., Trappenberg, T.P.(2015). Detection of event-related potentials in individual subjects using support vector machines. Brain Informatics. 2 (1), 1-12. doi: 10.1007/s40708-014-0006-7

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Connolly, J.F., Marchand, Y., Major, A., & D’Arcy, R.C.N. (2006). Event-related brain potentials as a measure of performance on WISC-III and WAIS-R NI Similarities sub-tests. Journal of Clinical and Experimental Neuropsychology. 28(8), 1327-1345. doi: 10.1080/13803390500428484

D’Arcy, R.C.N., Service, E., Connolly, J.F., & Hawco, C.S. (2005). The influences of increased working memory load on semantic neural systems: A high-resolution event-related brain potential study. Cognitive Brain Research. 22 (2), 177-191. doi: 10.1016/j.cogbrainres.2004.08.007

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FOOTNOTES

[1] The NeuroCatch^® Platform is a medical device registered with the U.S. Food & Drug Administration. FDA Device Listing: D476519.

[2] Fickling, S.D., Smith, A.M., Pawlowski, G., Ghosh Hajra, S., Liu, C.C., Farrell, K., Jorgensen, J., Song, X., Stuart, M.J., D'Arcy, R.C.N. (2019). Brain vital signs detect concussion-related neurophysiological impairment in ice-hockey. Brain, 142(2), 255-262. Editor's Choice.doi: 10.1093/brain/awy317

disclaimer

The content on this page describes future developments planned for the NeuroCatch^® Platform only.

NeuroCatch is a subsidiary of HealthTech Connex. Find out more about HealthTech Connex and its subsidiaries at healthtechconnex.com. HealthTech Connex is a part of the Lark Group of Companies.